The aim of this project is to collaborate with industry partners to develop comprehensive, system-level approaches for evaluating the resilience of large-scale infrastructure systems to climate change hazards. This is an urgent need as current industrial practices primarily utilize asset-level performance indicators to make crucial systemwide design and operational decisions for large-scale infrastructure systems such as transportation, water distribution, electricity, and communication. This project will serve as a foundation for creating new industry partnerships with the goal of providing them with the capability to utilize system-level approaches as predictive tools to address real-world infrastructure challenges associated with climate change that (i) radically improve resilience assessments leading to significant improvements in safety and cost savings and (ii) transform uncertainty management of critical assets, enabling a step change reduction in the associated operation and management costs. Ultimately, through collaboration with leading industry partners, the scientific and practical advancements gained through this project will revolutionize the resilience assessment for a wide range of real-world infrastructure systems of value to the USA.